The most challenging part of the 2024 NFL season for the Arizona Cardinals

Fact Checked by Washington Erick

As the Arizona Cardinals gear up for their second year under Jonathan Gannon’s leadership, it’s crucial to analyze which upcoming games will present the toughest obstacles for the team this season.

Despite facing challenges from their Week 1 matchup against the Buffalo Bills in New York to their Week 18 game against the San Francisco 49ers in Glendale, the Arizona Cardinals were able to secure their first postseason berth in two years.

The team at Bet365 Arizona has set the odds for the Cardinals this autumn, symbolizing a challenging path ahead with a projected win total of 6.5. utilized a point system to pinpoint the most difficult three-game stretch in the Arizona Cardinals’ 2024-25 NFL regular season schedule.

Best Choice
Caesars Sports
Best Choice
Must be 21+ and present in AZ. T&Cs apply.
Bonus Bets Expire in 7 Days. One New Customer Offer Only. Must be 21+ to participate & present in AZ. Gambling problem? Call 1-800-NEXT-STEP. Visit for Terms & Conditions. US promotional go-casinos not available in NY, NV, or Puerto Rico.
Must be a new verified Betway customer & present in AZ. 21+. Opt-in may be req'd. Make your first min. deposit of $10+, place a wager up to $250 (with odds of –300 (1.33) or greater (i.e. -300, -150, +150, etc.)) and receive up to $250 as bonus bet funds if the wager loses. Wager must be settled within 7 days from new account opening Gambling problem? Call 1-800-NEXT-STEP (AZ).
Must be 21+ and present in AZ. T&Cs apply.
Must be 21+ to participate & present in Arizona. Gambling Problem? Call 1-800-NEXT-STEP. Deposit required. Bonus Bets winnings are added to Bonus Bets balance. Bonus Bet wager excluded from returns. T&Cs Apply.
Must be 21+ to participate & present in Arizona. T&Cs apply. Play Responsibly. Gambling problem? Call 1-800-522-4700
Offered by Seminole Hard Rock Digital, LLC. Must be 21+ and physically present in AZ to play. T&Cs Apply. In AZ call 1-800-NEXT-STEP or text NEXTSTEP to 53342.
Must be 21+ to participate & present in Arizona. T&Cs apply. Gambling Problem? Call 1-800-NEXT-STEP.

The Method Behind Our Math

Points were given out according to the following rules:<br>- 1 point for facing a divisional opponent<br>- 1 point for playing on the road<br>- 1 point for participating in a primetime game (Thursday, Sunday, or Monday night)<br>- 2 points for playing on a short week<br>- 2 points for competing against a team ranked 11-20 on ESPN’s NFL Power Rankings<br>- 3 points for facing a team ranked 1-10 on ESPN’s NFL Power Rankings

Remain faithful to BetArizona for the best Arizona sportsbook deals throughout the entire season, with a special focus on the NFL season.

Toughest Part of Cardinals Regular Season





at San Francisco 49ers



at Green Bay Packers



vs. Los Angeles Chargers


What is Arizona’s most challenging three-game stretch in 2024?

In October, Arizona sports betting will face a tough challenge as the Cardinals take on two playoff teams on the road – the San Francisco 49ers on October 6th and the Green Bay Packers the following Sunday.

In addition to facing the rising Los Angeles Chargers on Monday Night Football in Jim Harbaugh’s first season with the team, Gannon’s squad is in for a tough midseason matchup against the Cardinals.

Arizona Cardinals have the eighth weakest strength of schedule in the NFL, tied with the Miami Dolphins and Seattle Seahawks. Their opponents’ win percentage, based on 2023 records, is .488, putting them behind the Philadelphia Eagles, Indianapolis Colts, and Tennessee Titans who each have a win percentage of .491.

Gannon and the Cardinals are determined to show the country their progress after two challenging seasons with consecutive 4-13 records in the Valley. Their biggest challenge will be in Week 5 of the NFL regular season when they go head-to-head with the defending NFC champions in Santa Clara.

Michael Chow took this photo for USA Today.


Peterson Christopher

Peterson Christopher, with over seven years of experience covering sports and sports betting in Arizona, has been appointed as the lead writer at He has also contributed to, the Tucson Weekly, and the Green Valley News in the past.

Top media outlets, such as those mentioned.