Preview of Betting Odds: The undefeated Arizona Cardinals are the favorites against the 49ers.

Betting Preview: Unbeaten Arizona Cardinals Favored vs. 49ers

The Arizona Cardinals have a chance to start the season 5-0 for the first time in almost 50 years this Sunday. Arizona sports betting odds show that the Cardinals are favored by 5.5 points for their home game.

The Arizona Cardinals will welcome the San Francisco 49ers, who are currently 2-2, to State Farm Stadium on Sunday. The game is scheduled to start at 1:25 p.m. in Arizona.

FOX will broadcast the upcoming game, showcasing Kyler Murray, the leading contender for the NFL Most Valuable Player award, as he takes on the 49ers defense, which currently ranks 10th in the league for yards allowed per game this season with 352.5.

Murray is the leading contender for MVP at multiple sportsbooks, with DraftKings Arizona giving him +450 odds and FanDuel Arizona offering +500 odds.

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Cardinals Favored Sunday

Three recently launched sports betting apps in Arizona – BetMGM Arizona, DraftKings Sportsbook, and FanDuel Sportsbook – all forecast a victory for the Cardinals over the 49ers, with Arizona favored by a spread of -5.5 points.

BetMGM offers odds of -227, DraftKings Sportsbook offers odds of -235, and FanDuel Sportsbook offers odds of -250 for moneyline wagers on the Arizona Cardinals.

The Cardinals have exceeded the spread in three out of four games this season, while the 49ers have only surpassed the spread once in four games when playing in Arizona in the NFL.

Super Bowl Contender?

The Cardinals’ strong start to the 2021 regular season has shifted perceptions of them from being ignored as Super Bowl contenders to being viewed as serious threats.

Arizona’s strong performance has made them one of the leading candidates to reach the Big Game, as BetMGM currently ranks them with the seventh-highest odds of winning the title at +1400.

Kliff Kingsbury’s team is listed at +1500 on TwinSpires Sportsbook Arizona, ranking them eighth in terms of odds among all NFL teams.

Recognized industry leaders such as Caesars Sportsbook Arizona, DraftKings Arizona, and FanDuel Arizona have set the Cardinals’ odds to win Super Bowl LVI at +1600, ranking them 8th in the league in terms of likelihood of victory.

Come face to face with the San Francisco 49ers.

The 49ers started the regular season with a mysterious pattern of wins against the Detroit Lions (41-33) and Philadelphia Eagles (17-11), but lost in close games to the Green Bay Packers (30-28) and Seattle Seahawks (28-21).

San Francisco’s offense has shown inconsistency this season, with quarterback Jimmy Garoppolo completing 66.1% of his passes for 925 yards and five touchdowns (with two interceptions). Despite this, the team has faced challenges in establishing a successful running game.

In two games this season, Elijah Mitchell, the leading rusher for the 49ers, has averaged 73 yards per game. Trey Sermon has also contributed with 128 yards and a touchdown so far.

The team has struggled with their running game, averaging only 3.9 yards per carry.

The San Francisco team is currently ranked 20th in yards per carry (YPC), but they have an opportunity to enhance their performance this Sunday against the Cardinals. The Cardinals defense is allowing 5.4 yards per carry, giving the San Francisco team a chance to capitalize on this weakness.

On Sunday, the Cardinals will either reach a milestone that has been five decades in the making or face a reality check following their strong start.

The Cardinals’ chances of winning the matinee will be determined by their ability to limit the 49ers’ rushing attack.



Peterson Christopher

Peterson Christopher, with over seven years of experience covering sports and sports betting in Arizona, now holds the position of lead writer at He has also contributed articles to, the Tucson Weekly, and the Green Valley News.

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